EVIDENCE-BASED MEDICINE: OBVIOUS BENEFITS AND HIDDEN DRAWBACKS

The article covers basic information on the comparative evaluation of drugs efficacy and safety from standpoint both clinical experience evidence-based medicine. It is emphasized that despite all its advantages evidencebased medicine does not contradict "opinion-based medicine". There have been presented rules for conducting randomized trials referred to as most modern method evidence collection. main criteria are described. At same time, it has drawbacks. them - inability transfer results obtained in a trial treatment patients with disease question. principle comparing between real-world data (RWD / RWE) described – project RCT DUPLICATE. author’s opinion drawbacks reporting presented. A number ethical issues evaluated. author claims selection optimal strategy particular patient should rely combination medicine, experience, historical well.